| 产品编号 : |
CL1015 |
| 产品名称 : |
Bexarotene |
| 中文名 : |
蓓萨罗丁 |
| CAS No. : |
153559-49-0 |
| 别名 : |
LGD 1069; LGD-1069;Bexarotene |
| 化学名称 : |
|
| 分子式 : |
C24H28O2 |
| 分子量 : |
348.48 |
| 结构式 : |
 |
| 外观 : |
White to off white crystalline powder |
| 纯度 : |
99+% |
| 应用 : |
Oncology |
| Registration : |
|
| Storage Condition : |
Bexarotene is a highly selective retinoid X receptor (RXR) agonist. It is an antineoplastic agent, already approved as an oral antineoplastic agent for cutaneous T cell lymphoma and being investigated against other cancers. A study has found that bexarotene in a mouse Alzheimer′s model lowered the most toxic form of β-amyloid peptide and increased cognitive ability. The activity in the mouse Alzheimer′s models are believed to be by activating PPARγ:RXR and LXR:RXR dimers which induces the expression of apoE and facilitates Aβ clearance and promotes microglial phagocytosis.
声明:
如果该化合物涉及专利保护，请勿作为商业目的使用，且仅供实验分析及研究之目的；如被销售到构成专利侵权的国家，则相应的一切风险将由买方承担。
