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ICG-001
产品编号 :
C13753
产品名称 :
ICG-001
中文名 :
CAS No. :
847591-62-2
别名 :
ICG 001; ICG001
化学名称 :
(6S,9aS)-Hexahydro-6-[(4-hydroxyphenyl)methyl]-8-(1-naphthalenylmethyl)-4,7-dioxo-N-(phenylmethyl)-2H-pyrazino[1,2-a]pyrimidine-1(6H)-carboxamide
分子式 :
C33H32N4O4
分子量 :
548.63
结构式 :
外观 :
纯度 :
98%Min.HPLC
应用 :
Registration :
Storage Condition :

Biological ActivitySpecific inhibitor of Wnt/β-catenin signaling pathway; inhibiting β-catenin/cyclic AMP response element-binding (CREB) protein transcription. ICG-001 selectively induces apoptosis in transformed cells but not in normal colon cells, reduces in vitro growth of colon carcinoma cells, and is efficacious in the Min mouse and nude mouse xenograft models of colon cancer.

声明:
如果该化合物涉及专利保护,请勿作为商业目的使用,且仅供实验分析及研究之目的;如被销售到构成专利侵权的国家,则相应的一切风险将由买方承担。

  • Biological ActivitySpecific inhibitor of Wnt/β-catenin signaling pathway; inhibiting β-catenin/cyclic AMP response element-binding (CREB) protein transcription. ICG-001 selectively induces apoptosis in transformed cells but not in normal colon cells, reduces in vitro growth of colon carcinoma cells, and is efficacious in the Min mouse and nude mouse xenograft models of colon cancer.
  • Resatorvid (TAK-242)

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