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PD 173074
| 产品编号 : |
C13990 |
| 产品名称： |
PD 173074 |
| 英文名： |
PD-173074(PD 173074) |
| 别名： |
PD 173074;PD-173074;PD173074 |
| 化学名称： |
N-[2-[[4-(Diethylamino)butyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)urea |
| CAS No. ： |
219580-11-7 |
| 结构式 ： |
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| 分子式： |
C28H41N7O3 |
| 分子量： |
523.67 |
| 溶解性： |
Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| 纯度： |
>99% |
| Usage: |
Selective FGFR1 and FGFR3 inhibitor (IC50 values are 5, 21.5, ~100, 17600 and 19800 nM for FGFR3, FGFR1, VEGFR2, PDGFR and c-Src respectively, and > 50000 nM for EGFR, InsR, MEK and PKC). Inhibits VEGF- and FGF-induced angiogenesis in the mouse cornea model of angiogenesis. Inhibits proliferation and differentiation of oligodendrocyte progenitors. Suppresses cell proliferation in cell lines expressing mutated FGFR3 protein. Blocks tumor growth in H510 and H69 SCLC xenograft models. |
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| 如果该化合物涉及专利保护，请勿作为商业目的使用，且仅供实验分析及研究之目的；如被销售到构成专利侵权的国家，则相应的一切风险将由买方承担。 |
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