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製品情報 - Reference Compounds - Reference Compounds
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DAPT (GSI-IX,LY-374973)
| カタログ : |
C13533 |
| 製品の名前: |
DAPT (GSI-IX,LY-374973) |
| 同義語: |
DAPT (enzyme inhibitor);GSI-IX;γ-Secretase Inhibitor IX;AN-37124 |
| 化学の名前: |
(2S)-N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-2-phenylglycine tert-butyl ester;N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenyl]glycine-1,1-dimethylethyl ester |
| CASナンバー : |
208255-80-5 |
| 構成 : |
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| 分子式: |
C23H26F2N2O4 |
| 分子量: |
432.46 |
| 溶解度: |
Soluble to 100 mM in DMSO |
| 純度: |
>99% |
| 使い方: |
Inhibitor of γ-secretase; causes a reduction in Aβ40 and Aβ42 levels in human primary neuronal cultures (IC50 values are 115 and 200 nM for total Aβ and Aβ42 respectively) and in brain extract, cerebrospinal fluid and plasma in vivo. Does not effect APPα and APPβ levels. Blocks Notch signaling in hybrid human-mouse fetal thymus organ culture (FTOC). Activity causes neural cells to commit to neuronal differentiation. |
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| 制品、有效に関する特許保護を売却せず、国家、売却こうした製品の特許侵害金人で、それは私たちの知らない特許の情况は全ての国、特許侵害責任は、十分に理解できるをバイヤーのリスクを高める. |
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