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Ascomycin(FK 520)

  Catalogue No. : C13319
  Product Name: Ascomycin(FK 520)
  Synonym: Changchuanmycin; FK 520; FR 520; FR 900520; Immunomycin; L 683590;FK-520;FR-900520
  Chemical Name: (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-8-Ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)tetrone
  CAS No. : 104987-12-4(11011-38-4)
  Structure :
  Molecular Formula: C43H69NO12
  Molecular Weight: 792.01
  Appearance: White lyophilised solid
  Solubility: Soluble in DMSO and ethanol
  Purity: >98%
  Usage: Analog of FK 506;binds to FK 506-binding protein 12 (FKBP12) in order to inhibit calcineurin phosphatase activity (IC50 = 49 nM) and activation of nuclear factor of activated T cells (NFAT). Displays antifungal and immunosuppressive activities.
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