Ascomycin(FK 520)
Catalogue No. : |
C13319 |
Product Name: |
Ascomycin(FK 520) |
Synonym: |
Changchuanmycin; FK 520; FR 520; FR 900520; Immunomycin; L 683590;FK-520;FR-900520 |
Chemical Name: |
(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-8-Ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)tetrone |
CAS No. : |
104987-12-4(11011-38-4) |
Structure : |
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Molecular Formula: |
C43H69NO12 |
Molecular Weight: |
792.01 |
Appearance: |
White lyophilised solid |
Solubility: |
Soluble in DMSO and ethanol |
Purity: |
>98% |
Usage: |
Analog of FK 506;binds to FK 506-binding protein 12 (FKBP12) in order to inhibit calcineurin phosphatase activity (IC50 = 49 nM) and activation of nuclear factor of activated T cells (NFAT). Displays antifungal and immunosuppressive activities. |
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