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PD 158780(PD158780)
| Catalogue No. : |
C16370 |
| Product Name: |
PD 158780(PD158780) |
| Synonym: |
PD158780 |
| Chemical Name: |
N4-(3-Bromophenyl)-N6-methyl-pyrido[3,4-d]pyrimidine-4,6-diamine;4-[(3-Bromophenyl)amino]-6-(methylamino)-pyrido[3,4-d]pyridimine |
| CAS No. : |
171179-06-9 |
| Structure : |
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| Molecular Formula: |
C14H12BrN5 |
| Molecular Weight: |
330.18 |
| Purity: |
>98% |
| Usage: |
Potent inhibitor of ErbB receptor family tyrosine kinases (IC50 values are 0.008, 49 and 52 nM for EGFR, ErbB2 and ErbB2/ErbB4 respectively) that does not inhibit FGF or PDGF-mediated tyrosine phosphorylation. Induces G1 cell cycle arrest in MCF10A cells and is antiproliferative in A431 human epidermal carcinoma cells. |
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