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Products - Active Pharma Ingredients(API) - Anti-Cancer(Oncology) API
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VX-680(MK-0457,Tozasertib)
| Catalogue No. : |
C14340 |
| Product Name: |
VX-680(MK-0457,Tozasertib) |
| Synonym: |
Tozasertib,MK 0457 |
| Chemical Name: |
N-[4-[4-(4-Methylpiperazin-1-yl)-6-(3-methyl-1H-pyrazol-5-ylamino)pyrimidin-2-sulfanyl]phenyl]- cyclopropanecarboxamide |
| CAS No. : |
639089-54-6 |
| Structure : |
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| Molecular Formula: |
C23H28N8OS |
| Molecular Weight: |
464.59 |
| Appearance: |
White or pale yellow powder |
| Solubility: |
Soluble in DMSO;very poorly soluble in ethanol and water |
| Purity: |
>99% |
| Usage: |
Potent inhibitor of aurora kinases with Ki values to be 0.6, 18 and 4.6 nM for auraro A, B and C isotypes respectively; inhibiting also ABL (Ki=30 nM) and FLT3 (Ki=30 nM) kinases. |
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