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Bexarotene
Product Number :
C13375
Product Name :
Bexarotene
CAS No. :
153559-49-0
Synonyms :
LGD 1069; LGD-1069
Chemical Name :
Molecular Formula :
C24H28O2
Molecular Weight :
348.48
Molecular Structure :
Appearance :
Specification :
Application :
Oncology
Registration :
Storage Condition :

Bexarotene is a highly selective retinoid X receptor (RXR) agonist. It is an antineoplastic agent, already approved as an oral antineoplastic agent for cutaneous T cell lymphoma and being investigated against other cancers. A study has found that bexarotene in a mouse Alzheimer′s model lowered the most toxic form of β-amyloid peptide and increased cognitive ability. The activity in the mouse Alzheimer′s models are believed to be by activating PPARγ:RXR and LXR:RXR dimers which induces the expression of apoE and facilitates Aβ clearance and promotes microglial phagocytosis.

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